Asymmetric total synthesis of (+)-fumimycin via 1,2-addition to ketimines.
نویسندگان
چکیده
The first asymmetric total synthesis of fumimycin was accomplished. As a key step, a 1,2-addition of methyl Grignard reagents to ketimines with quinine as additive was employed. The absolute configuration of (+)-fumimycin was determined by CD-spectroscopy combined with time-dependent density functional calculations.
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عنوان ژورنال:
- Chemical communications
دوره 46 48 شماره
صفحات -
تاریخ انتشار 2010